Oncology Research

Discovering new paths shape the delivery of cancer treatments

Cancer is among the leading cause of death worldwide. We have four centers dedicated to the most vital areas of cancer research – clinical trials, basic research and translational research – in order to better understand cancer, and to find new paths for shaping and delivering the best, most effective cancer treatments.

Northwell Health Cancer Center: Northwell Health Cancer Institute is comprised of specialists who have expertise in research, prevention and post-treatment care.

Karches Center for Oncology: Researchers in this Center study cancer and cell biology to better understand the abnormal growth and behavior of malignant cells. Discoveries in the Center are used to develop and test new diagnostics and treatments for a variety of cancers. Two of our focus areas are chronic lymphocytic leukemia (CLL), a type of cancer of the blood and bone marrow, and human papillomaviruses (HPVs), a family of viruses that cause a wide range of benign and malignant tumors that range from common skin warts to cervical cancer.

Brain Tumor Biotech CenterThis Center is an interactive hub for scientists, clinicians and biotech companies in the neuro-oncology space to join forces and accelerate the delivery of novel drugs to patients living with brain tumors. We study brain and spinal cord tumors, which are very life-threatening – the median life expectancy for a glioblastoma patient, for example, is 15 months after diagnosis. Because in most cases of brain cancer, treatment options are largely limited to surgery, radiation, and chemotherapy, we are working to discover new and better treatments by designing and testing new drugs and drug delivery methods.

Cohen’s Children’s Medical Center: The Division of Hematology/Oncology and Stem Cell Transplantation at the Cohen Children’s Medical Center combines expertise in laboratory science, genetics/genomics, epidemiology and clinical trials with excellent patient care to examine the causes of pediatric cancer and blood disorders, and translate this knowledge into treatments. Recent collaborations with the Cold Spring Harbor Laboratories Cancer Center will expand our reach in developmental therapeutics for cancer.Clinical stemming from our staff’s translational activities are coordinated by PHOTO (the Pediatric Hematology/Oncology Trials Office).

Feinstein Institute researchers are making progress in identifying new treatments for two of the most common types of brain tumors, glioblastoma and medulloblastoma. Areas of active research include modulating the immune system to improve the therapeutic response in glioblastoma and identifying new therapies that can allow the use of lower doses of radiation in young children with medulloblastoma. In addition, new methods of how best to guide neurosurgeons during surgery with imaging devices are being tested in clinical trials.