Larry Miller, MD

Director, Gastroenterology Laboratory, The Feinstein Institute for Medical Research

Chief, Gastroenterology, Northwell Health

Professor of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Phone: (718) 470-4691

About the Investigator

Dr. Miller is a third tier trained therapeutic endoscopist and is board certified in internal medicine, gastroenterology and clinical nutrition. In addition, he is a trained bench lab and clinical research scientist, having completed a three year research fellowship at the Digestive Disease Section of the NIDDK. He currently hold the position as Chief of Gastroenterology Zucker School of Medicine. Dr. Miller has spent the last 30 years of his clinical career as a therapeutic endoscopist, performing ERCP and EUS. He spent much of his research career as head of endoscopic research at both Thomas Jefferson University and at Temple University in Philadelphia.

Part of Dr. Miller’s research interests are the design and invention of endoscopic devices. He has invented and patented a number of different endoscopic devices. In the early 1990’s, he invented a method using simultaneous high-resolution ultrasound and manometry to study the anatomy and physiology of gastrointestinal sphincters. Over the last 25 years of his academic career he used this technology to studying the anatomy and physiology of gastrointestinal sphincters and has published extensively on the anal sphincter, the lower esophageal sphincter, the upper esophageal sphincter, and the pyloric sphincter. As part of his NIH sponsored research work he studies the mechanics, physiology and pathophysiology of the high pressure zone of the distal esophagus.

Dr. Miler’s first RO1 grant dealt specifically with normal sphincter function and physiology of the distal esophageal anti-reflux barrier. In that grant he defined the anatomic and physiologic components of the distal esophageal high-pressure zone. Dr. Miller’s second NIH RO1 grant investigated the pathophysiology of GERD. Performing bench lab studies on muscle preparations from stomachs and esophagi of organ transplant donors and clinical studies, his lab discovered a number of new pathophysiologic mechanisms in GERD. These include 1) A contractile defect within the clasp/sling fiber complex. 2) Excessive relaxation of the clasp and sling fiber complex to nicotinic stimulation. 3) An abnormality within the muscularis mucosa in patients with GERD during deglutition. 4) Abnormal compliance of the gastroesophageal junction using various methods. 5) An attenuated cholinergic pressure profile within the circular smooth muscle of the distal esophagus. Dr. Millers current U18 NIH grant uses new techniques to implant gastric pacemakers in the submucosal space of the gastrointestinal tract.

Research Focus

For over 30 years, Dr. Miller has taught, researched and worked in the area of gastrointestinal physiology with a focus on sphincter mechanisms in the GI tract. As a principal investigator or co-investigator on several NIH-funded grants regarding the physiology and pathophysiology of the anti-reflux barrier at the gastroesophageal junction, he fully understands the time and commitment required to execute a research study effectively and efficiently.

Lab Members

Anil Vegesna, MD, MPH
Research Scientist

Benley J George, MD, MHSA
Senior Clinical Research Coordinator

Cailin S. Grant, BS
Research Coordinator

Molly Stewart, BS
Research Coordinator


The Chicago Medical School
Degree: MD
Field of Study: Medicine

University of Illinois
Degree: BS
Field of Study: Biology & Chemistry

Honors and Awards

2012-Present Chief of Gastroenterology, Professor of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, North Shore-LIJ Health System, Manhasset, NY
2012 Golden Apple teaching award for best teacher at Temple University Medical School, Philadelphia, PA
2006-2012 Professor of Medicine, Associate Director of Gastrointestinal Endoscopy; Director of Endoscopic Research, Temple University School of Medicine, Philadelphia, PA
2004 Member, Million Dollar Research Award Club, Temple University, Philadelphia, PA
1997-2006 Associate Professor of Medicine; Associate Director of Gastrointestinal Endoscopy; Director of Endoscopic Research, Temple University School of Medicine, Philadelphia, PA
1993-1997 Assistant Professor of Medicine, Director of Endoscopic Research, Temple University School of Medicine, Philadelphia, PA
1990-1993 Assistant Professor of Medicine, Director of Medical Endoscopy, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA
1989-1990 Therapeutic Endoscopy Fellowship, The Wellesley Hospital, University of Toronto, Toronto, Canada
1986-1989 Clinical and Research Fellowship in Gastroenterology, Georgetown University/Washington VA/NIH. Washington D.C.
1984-1986 Fellowship in Clinical Nutrition, Midwest Nutrition, Education and Research Foundation, Chicago, IL
1981-1984 Medical Internship, Junior and senior residency, Evanston Hospital, Northwestern University Training Program in Internal Medicine, Evanston, IL
1973 Awarded membership Phi Eta Sigma Honor Society, Chicago, IL1973 Awarded full scholarship from Department of Music University of Illinois, Chicago, IL
1976 Awarded membership, Phi Kappa Phi Honor Society, Chicago, IL

  1. Miller LS, Vegesna AK, Braverman AS, Barbe MF, Ruggieri MR, Sr. “Enhanced nicotinic receptor mediated relaxations in gastroesophageal muscle fibers from Barrett’s esophagus patients.” Neurogastroenterology and Motility. 2013;Early View(3):1-10. Epub 15 Dec 2013 doi: 10.1111/nmo.12294. PubMed PMID: 24330081; PMCID: PMID: 24330081
  2. Miller LS, Vegesna AK, Sampath AM, Prabhu S, Kotapati SK, Makipour K. “Leocecal valve dysfunction in small intestinal bacterial overgrowth: A pilot study.” World J Gastroenterol. 2012;18(46):6801-8. doi: doi: 10.3748/wjg.v18.i46.6801. PubMed PMID: 23239918; PMCID: PMC3520169.
  3. Vegesna A, Besetty R, Kalra A, Farooq U, Korimilli A, Chuang KY, Fisher R, Parkman H, Miller L. “Induced opening of the gastroesophageal junction occurs at a lower gastric pressure in gerd patients and in hiatal hernia subjects than in normal control subjects.” Gastroenterol Res Pract. 2010;2010:857654. doi: PubMed PMID: 20339562; PMCID: PMC2842887.
  4. Miller L, Dai Q, Vegesna A, Korimilli A, Ulerich R, Schiffner B, Brassuer J. “A missing sphincteric component of the gastro-oesophageal junction in patients with GORD.” Neurogastroenterol Motil. 2009;21(8):813-e52. doi: PubMed PMID: 19368661; PMCID: NIHMS120814 PMC2746096
  5. Dai Q, Korimilli A, Thangada VK, Chung CY, Parkman H, Brasseur J, Miller LS. “Muscle shortening along the normal esophagus during swallowing.” Dig Dis Sci. 2006;51(1):105-9. PubMed PMID: 16416220.
  6. Liu JB, Miller LS, Goldberg BB, Feld RI, Alexander AA, Needleman L, Castell DO, Klenn PJ, Millward CL. “Transnasal US of the esophagus: preliminary morphologic and function studies.” Radiology. 1992;184(3):721-7. PubMed PMID: 1509056.
  7. Miller L, Dai Q, Korimilli A, Levitt B, Ramzan Z, Brasseur J. “Use of endoluminal ultrasound to evaluate gastrointestinal motility.” Digestive diseases (Basel, Switzerland). 2006;24(3-4):319-41. Epub 2006/07/20. doi: 10.1159/000092886. PubMed PMID: 16849860.
  8. Vegesna AK, Chuang KY, Besetty R, Phillips SJ, Braverman AS, Barbe MF, Ruggieri MR, Miller LS. “Circular smooth muscle contributes to esophageal shortening during peristalsis.” World Journal of Gastroenterology. 2012;18(32):4317-22. PubMed PMID: 22969194; PMCID: PMC3436046.
  9. Nicosia MA, Brasseur JG, Liu JB, Miller LS. “Local longitudinal muscle shortening of the human esophagus from high-frequency ultrasonography.” Am J Physiol Gastrointest Liver Physiol. 2001;281(4):G1022-33. PubMed PMID: 11557523.

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