Harold A. Silverman, PhD

Member, Center for Bioelectronic Medicine and Biomedical Science, The Feinstein Institute for Medical Research

Phone:: (516) 562-1127
Email:  hsilverman@northwell.edu

About the Investigator

Harold Silverman began his studies at Binghamton University, earning a Bachelor of Science degree in Anthropology in 2010 and a Master of Science degree in Biomedical Anthropology in 2012. He went on to earn his Doctor of Philosophy in the Molecular Basis of Medicine from the Donald and Barbra Zucker School of Medicine in 2018. His PhD work was done in the Laboratory of Biomedical Sciences at the Feinstein Institute for Medical Research under the mentorship of Dr. Kevin J. Tracey and Dr. Sangeeta S. Chavan. There, Dr. Silverman studied the inflammatory reflex, focusing on understanding the role of sensory vagus nerve signaling in inflammation. His work has been presented at national and international conferences including the SHOCK society meeting, the Society for Neuroscience and at the 13th Key Symposium on Bioelectronic Medicine.

Research Focus

Dr. Silverman is interested in understanding vagus nerve signaling in the inflammatory reflex. He began by studying the forebrain cholinergic system’s control over peripheral inflammation with. His current research focus is on understanding how peripheral inflammation signals to the brain through the afferent arm of the inflammatory reflex. During his studies he helped develop and standardize a methodology for recording cervical vagus nerve activity in mice.  He uses this methodology to discern specific signaling mechanisms both electrically and molecularly through the afferent arm of the inflammatory reflex.


SUNY Binghamton University
Degree: Bachelor of Science
Field of Study: Anthropology

SUNY Binghamton University
Degree: Bachelor of Science
Field of Study: Biomedical Anthropology

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Degree: PhD
Field of Study: Molecular Basis of Medicine

Awards & Honors

2017 Poster Presenter Award, Annual Feinstein Institute Scientific Retreat

  1. Silverman, H.A., Stigler, A., Tsaava, T., Newnan, J., Steinberg, B.E., Battinelli, E.A., Robbiati, S., Bouton, C., Huerta, P.T., Chavan,   S.S., Tracey, K.J. (2017) Vagus Nerve Activity: Peripheral Nerve Recording in Mice. Bioelectronic Medicine, Vol 4.
  2. Nahla Zaghloul, Meghan Addorisio, Harold A. Silverman, Hardik L. Patel, Sergio I. Valdes Ferrer, Kamesh R. Ayasolla, Kurt R. Lehner, Peder S. Olofsson, Mansoor Nasim, Christine N. Metz, Ping Wang, Mohamed Ahmed, Sangeeta S. Chavan, Betty Diamond, Kevin J. Tracey, Valentin A. Pavlov (2017) Forebrain cholinergic dysfunction and systemic and brain inflammation in murine sepsis survivors. Frontiers in Immunology, 8.
  3. Caravaca, A. S., Tsaava, T., Goldman, L., Silverman, H., Riggott, G., Chavan, S., Bouton, C., Tracey, K. J., Desimone, R., Boyden, E., Sohal, H. S. and Olofsson, P. S. (2017). A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve. Journal of neural engineering, 14(6), 066005.
  4. Steinberg, B. E.*, Silverman, H. A.*, Robbiati, S., Gunasekaran, M. K., Tsaava, T., Battinelli, E., Stiegler, A., Bouton, C. E., Chavan, S. S., Tracey, K. J. and Huerta, P. T. (2016) ‘Cytokine-specific Neurograms in the Sensory Vagus Nerve. Bioelectronic Medicine’, Bioelectronic Medicine, Bioelectronic Medicine 2016, pp. 7-17
  5. Hudson, L. K., Dancho, M. E., Li, J., Bruchfeld, J. B., Ragab, A. A., He, M. M., Bragg, M., Lenaghan, D., Quinn, M. D., Fritz, J. R., Tanzi, M. V., Silverman, H. A., Hanes, W. M., Levine, Y. A., Pavlov, V. A., Olofsson, P. S., Roth, J., Al-Abed, Y., Andersson, U., Tracey, K. J. and Chavan, S. S. (2016) ‘Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice’, Mol Med, pp. 585-96
  6. Silverman, H. A., M. Dancho, A. Regnier-Golanov, M. Nasim, M. Ochani, P. S. Olofsson, M. Ahmed, E. J. Miller, S. S. Chavan, E. Golanov, C. N. Metz, K. J. Tracey, and V. A. Pavlov. (2015). Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation." Mol Med 20:601-11.

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