Daniel A. Grande, PhD

Associate Professor, Center for Bioelectronic Medicine, The Feinstein Institute for Medical Research

Director, Orthopaedic Research Laboratory, The Feinstein Institute for Medical Research

Associate Professor, Molecular Medicine and Orthopedic Surgery,
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Phone: (516) 562-1138
Email: dgrande@northwell.edu

About the Investigator

Dr. Grande is associate investigator and director of Orthopaedic Research at the Feinstein Institute for Medical research. He is also associate professor at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. He completed his PhD at New York University and his post-doctoral fellowship ion biomechanics at the Hospital for Special Surgery. He has worked extensively in the area of regenerative medicine and tissue engineering. His early work developed the first use of cell based therapy for cartilage repair, currently known as autologus chondrocyte transplantation.

He is the author of over 80 peer review publications and five book chapters. He has served on committees with the Orthopaedic Research Society as spine topic chair and on the basic science committee. Dr, Grande is significantly involved in mentoring and teaching of orthopaedic residents for his department. He has been a reviewer for a number of journals including: Journal of Orthopaedic Research, Clinical Orthopaedics, Osteoarthritis and Cartilage, American Journal of Sports Medicine, Nature Reviews Rheumatology and Journal of Applied Biomaterials.

Dr. Grande has been awarded eight patents and helped found two companies in the orthopaedic surgery field of use. He has also served as a member of the scientific advisory boards for several companies. He completed a five year rotation with OREF to assist in grant reviews, and regularly serves on NIH study sections for RO1, R21, and SBIR/STTR grants specific to musculoskeletal applications.

Research Focus

Dr. Grande’s research aims to improve treatments for injuries of the musculoskeletal system, including cartilage regeneration and repair, meniscus repair, tendon repair and bone fracture augmentation and fusion.

Dr. Grande is widely recognized as a world leader in cartilage repair. He pioneered the first cell-based therapy for articular cartilage repair. These studies led to the commercialization of cartilage transplantation for the current surgical treatment of focal cartilage defects in clinical use today — autologous chondrocytes transplantation.

Recently, he and his collaborators have been developing novel cell-modified scaffolds for enhancing tendon repair as well as innovative methods to provide osteogenic and osteoconductive gene therapy and tissue-engineered constructs for providing abundant bone graft substitutes for bone injuries.

The lab recently received an instrument Instron 5566 material testing system. This will allow students and residents to make strides in determining the strength of various orthopedic constructs such as fracture stiffness of bone and the strength of tendon repairs. The team is collaborating with Sleiman Ghoryeb, PhD, an engineer at Hofstra University. He will be examining the utility of ultrasound imaging for assessing cartilage repair.

The overarching objectives of Dr. Grande’s proposed research program involve mechanistic concepts for the causality of degenerative disc disease. In this application he will fulfill his role of co-investigator by collaborating in his area of expertise: cartilage biology and repair. This is an area in which he has spent his entire career conducting research, and has resulted in currently FDA-approved cell based therapies, eg. autologous chondrocyte transplantation [ACI]. The focus of this grant application is the early events that result in disc degeneration. This is a concept that Dr. Grande and his group have been developing over the last two years, performing numerous studies which have been documented in peer review publications. As part of this application, his team will be performing all of biomechanics testing and histology.  Successful completion of the research objectives of this application would have broad impact in the area of the spine, which is a major health care burden for the USA.

Lab Members

Pasquale Razzano, MS
Lab Manager

John Schwartz, BS
Research Assistant

Erich Brandel, BS
Research Assistant

Adam Lin
Student Intern

Todd Goldstein, MS


Long Island University
Degree: BS
Field of Study: Biology/Chemistry

New York University
Degree: PhD
Field of Study: Anatomy/Cell Biology

Hospital for Special Surgery
Degree: Post-doc
Field of Study: Biomechanics


1986-1989 Adjunct Assistant Professor of Anatomy, New York University College of Dentistry, New York, NY
1987-1990 Research Assistant Professor of Orthopaedic Surgery, New York University School of Medicine
New York, NY
1989 Adjunct Associate Professor of Anatomy, New York University College of Dentistry, New York, NY
1990-1995 Assistant Professor of Anatomy and Cell Biology, Cornell University Medical College, New York, NY
1995-present Associate Professor of Orthopaedic Surgery, Albert Einstein College of Medicine New York, NY
2009-present Inaugural faculty Hofstra School of Medicine

Awards & Honors

1989 Fabian Scientific Award
1990 Arthroscopy Association of North America Resident Research Award
2001 American Orthopaedic Association Resident Research Award (NE Region)
2001 American Orthopaedic Association/Zimmer Award Resident Research Award
2001 Orthopaedic Research and Education Foundation NE Region Resident Competition
2004 Charles S. Neer, MD Award
2007 Arthur Weber, MD Memorial Resident Appreciation Award
2007 Northwell Health Outstanding Teacher Award
2012 Ranawat Award: Eastern Orthopedic Association

  1. Cummings S, Grande DA, Hee CK, Kestler HK,Roden CM, Shah N, Razzano P, Dines DM, Chahine NO, & JS Dines: “Effect of Recombinant Human Platelet-Derived Growth Factor BB coated Sutures on Achilles Tendon Healing in a Rat model: A Histological and Biomechanical Study” J of Tissue Engineering; 3(1):2041731412453577, 2012
  2. Ghorayeb S, Shah N, Edobor-Osula F, Lane L, Razzano P, Chahine N, and DA Grande: “Ultrasonic Assessment of Extracellular Matrix Content in Healing Achilles Tendon” Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Vol. 59 (4), 694. 2012
  3. Bedi A, Maak T, Walsh C, Rodeo S, Grande D, Dines D, Dines J: “Cytokines in rotator cuff Degeneration and Repair” J. Shoulder and Elbow Surgery 21 (2) 218-227, 2012
  4. Pleshko N, Grande D, and KR Meyers: “Nanotechnology in Orthopaedics” J. Am Acad. Orthop. Surg. Jan; 20(1):60-2, 2012.
  5. Gott M, Ast M, Lane L, Schwartz J, Catanzano A, Razzano P, and D Grande: “Tendon Phenotype Should Dictate Tissue Engineering Modality in Tendon Repair: A Review.” Discovery Medicine 12 (62): 75-84, 2011.
  6. Dines JS, Cross MB, Dines D, Pantazopoulos C, Kim HJ, Razzano P, Grande D: “In vitro analysis of an rhGDF-5 suture coating process and the effects of rhGDF-5 on rat tendon fibroblasts.” Growth Factors. Feb;29(1):1-7. 2011
  7. Grande D, Shah N, Catanzano A, Nelson F, Hoey D, Jacobs C: “On the Horizon from ORS: Regeneration of Cartilage Surfaces.” Journal of the American Academy of Orthopaedic Surgeons. 19, 59-62. 2011
  8. Grande D & N. Sgaglione: “Self Directed Articular Resurfacing: A New Paradigm?” News and Views Commentary; Nature Reviews Rheumatology. Vol. 6, 677 Dec. 2010
  9. Henn F, Kuo C, Kessler M, Razzano P, Grande D, and S. Wolfe: “Augmentation of Zone II Flexor Tendon Repair Using Growth Differentiation Factor 5 in a Rabbit Model.” Journal of Hand Surgery. 35A, 1825-1832. 2010
  10. Uggen C, Dines J, Dines D, McGarry M, Grande D, Lee T, and O Limpivasti: “The Effect of rhPDGF-BB Coated Sutures on Rotator Cuff Healing in a Sheep Model.” Arthroscopy; 26, No.11, 1456-1462. 2010
  11. Rosenbaum A, Wicker J, Dines J, Bonasser L, Razzano P, Dines D, and Grande DA: “Histologic Stages of Healing Correlate with Restoration of Tensile Strength in a Model of Experimental Tendon Repair.” Hospital for Special Surgery Journal. Vol.6.,164-170. 2010

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